ANSWERS to HOMEWORK 9

1. Click here to see the phosphatease domain sequence. The top three templates to use for the model building are 1bg1a3, 2jwoa_ and 1fu6a_.

2. The model was built with the SWISS_MODEL program, and can be found in the file pdb. You can dowload it, and view with one of the molecular visualization applications discussed in lecture.

3. The related structures to this model from the DALI website are listed below:

   PDB #             Name
   2shp-A    shp-2 (syp, shptp-2) Mutant 
   1d4t-A    t cell signal transduction molecule sap fragment 
   1a81-A    syk kinase fragment t-cell surface glycoprotein 
   1qad-A    pi3-kinase p85 alpha subunit fragment 
   2cbl-A    proto-oncogene cbl fragment zap-70 fragment