Peter Reddien
Principal Investigator
Email Address: reddien at wi.mit.edu

Publications

Wurtzel O, Oderberg IM, Reddien PW. (2017). Planarian Epidermal Stem Cells Respond to Positional Cues to Promote Cell-Type Diversity. Dev Cell 40(5), 491-504.

LoCascio SA, Lapan SW, Reddien PW. (2017). Eye Absence Does Not Regulate Planarian Stem Cells during Eye Regeneration. Dev Cell 40(4), 381-391.

Oderberg IO, Li DJ, Scimone ML, Gavino MA, Reddien PW. (2017). Landmarks in Existing Tissue at Wounds Are Utilized to Generate Pattern in Regenerating Tissue. Curr Biol 27(5), 733-742.

Carmell MA, Dokshin GA, Skaletsky H, Hu YC, van Wolfswinkel JC, Igarashi KJ, Bellott DW, Nefedov M, Reddien PW, Enders GC, Uversky VN, Mello CC, Page DC. (2016). A widely employed germ cell marker is an ancient disordered protein with reproductive functions in diverse eukaryotes. eLife 5(e19993).

Wang IE, Lapan SW, Scimone ML, Clandinin TR, Reddien PW. (2016). Hedgehog signaling regulates gene expression in planarian glia. eLife 5(e16996).

Scimone ML, Cote LE, Rogers T, Reddien PW. (2016). Two FGFRL-Wnt circuits organize the planarian anteroposterior axis. eLife 5(e12845).

Wurtzel O, Cote LE, Poirier A, Satija R, Regev A, and Reddien PW. (2015). A Generic and Cell-Type-Specific Wound Response Precedes Regeneration in Planarians. Dev Cell 35(5), 632-45.

Owen JH, Wagner DE, Chen CC, Petersen CP, and Reddien PW. (2015). teashirt is required for head-versus-tail regeneration polarity in planarians. Development 142(6), 1062-72.

Scimone ML, Kravarik KM, Lapan SW, and Reddien PW. (2014). Neoblast specialization in regeneration of the planarian Schmidtea mediterranea. Stem Cell Reports 3(2), 339-52.

van Wolfswinkel JC, Wagner DE, and Reddien PW. (2014). Single-Cell Analysis Reveals Functionally Distinct Classes within the Planarian Stem Cell Compartment. Cell Stem Cell 15(3), 326-339.

Srivastava M, Mazza-Curll KL, van Wolfswinkel JC, and Reddien PW. (2014). Whole-body acoel regeneration is controlled by Wnt and Bmp-Admp signaling. Curr Biol 24(10), 1107-13.


Reddien PW. (2013). Lin28: time for tissue repair. Cell 155(4), 738-9.

Gavino MA, Wenemoser D, Wang IE, and Reddien PW. (2013). Tissue absence initiates regeneration through Follistatin-mediated inhibition of Activin signaling. Elife 2, e00247.

Witchley JN, Mayer M, Wagner DE, Owen JH, and Reddien PW. (2013). Muscle cells provide instructions for planarian regeneration. Cell Rep 4(4), 633-41.

Reddien PW. (2013). Specialized progenitors and regeneration. Development 140(5), 951-7.

Chen CC, Wang IE, and Reddien PW. (2013). pbx is required for pole and eye regeneration in planarians. Development 140(4), 719-29.


Wenemoser D, Lapan SW, Wilkinson AW, Bell GW, and Reddien PW. (2012). A molecular wound response program associated with regeneration initiation in planarians. Genes Dev 26(9), 988-1002.


Scimone ML, Srivastava M, Bell GW, and Reddien PW. (2011). A regulatory program for excretory system regeneration in planarians. Development 138(20), 4387-98.

Lapan SW and Reddien PW. (2011). dlx and sp6-9 Control optic cup regeneration in a prototypic eye. PLoS Genet 7(8), e1002226.

Tanaka EM and Reddien PW. (2011). The cellular basis for animal regeneration. Dev Cell 21(1), 172-85.



Wagner DE, Wang IE, and Reddien PW. (2011). Clonogenic neoblasts are pluripotent adult stem cells that underlie planarian regeneration. Science 332(6031), 811-6.


Wenemoser D and Reddien PW. (2010). Planarian regeneration involves distinct stem cell responses to wounds and tissue absence. Dev Biol 344(2), 979-91.

Scimone ML, Meisel J, and Reddien PW. (2010). The Mi-2-like Smed-CHD4 gene is required for stem cell differentiation in the planarian Schmidtea mediterranea. Development 137(8), 1231-41.

Petersen CP and Reddien PW. (2009). Wnt signaling and the polarity of the primary body axis. Cell 139(6), 1056-68.

Glazer AM, Wilkinson AW, Backer CB, Lapan SW, Gutzman JH, Cheeseman IM, and Reddien PW. (2010). The Zn finger protein Iguana impacts Hedgehog signaling by promoting ciliogenesis. Dev Biol 337(1), 148-56.

Petersen CP and Reddien PW. (2009). A wound-induced Wnt expression program controls planarian regeneration polarity. Proc Natl Acad Sci U S A 106(40), 17061-6.

Reddien PW, Newmark PA, and Sanchez Alvarado A. (2008). Gene nomenclature guidelines for the planarian Schmidtea mediterranea. Dev Dyn 237(11), 3099-101.


Reddien PW, Bermange AL, Kicza AM, and Sánchez Alvarado A. (2007). BMP signaling regulates the dorsal planarian midline and is needed for asymmetric regeneration. Development 134(22), 4043-51.


Reddien PW, Oviedo NJ, Jennings JR, Jenkin JC, and Sánchez Alvarado A. (2005). SMEDWI-2 is a PIWI-like protein that regulates planarian stem cells. Science 310(5752), 1327-30.

Reddien PW, Bermange AL, Murfitt KJ, Jennings JR, and Sánchez Alvarado A. (2005). Identification of genes needed for regeneration, stem cell function, and tissue homeostasis by systematic gene perturbation in planaria. Dev Cell 8(5), 635-49.

Reddien PW and Sánchez Alvarado A. (2004). Fundamentals of planarian regeneration. Annu Rev Cell Dev Biol 20, 725-57.

Reddien PW and Horvitz HR. (2004). The engulfment process of programmed cell death in Caenorhabditis elegans. Annu Rev Cell Dev Biol 20, 193-221.

Newmark PA, Reddien PW, Cebrià F, and Sánchez Alvarado A. (2003). Ingestion of bacterially expressed double-stranded RNA inhibits gene expression in planarians. Proc Natl Acad Sci U S A 100 Suppl 1, 11861-5.

Lundquist EA, Reddien PW, Hartwieg E, Horvitz HR, and Bargmann CI. (2001). Three C. elegans Rac proteins and several alternative Rac regulators control axon guidance, cell migration and apoptotic cell phagocytosis. Development 128(22), 4475-88.

Reddien PW, Cameron S, and Horvitz HR. (2001). Phagocytosis promotes programmed cell death in C. elegans. Nature 412(6843), 198-202.

Reddien PW and Horvitz HR. (2000). CED-2/CrkII and CED-10/Rac control phagocytosis and cell migration in Caenorhabditis elegans. Nat Cell Biol 2(3), 131-6.

Shaham S, Reddien PW, Davies B, and Horvitz HR. (1999). Mutational analysis of the Caenorhabditis elegans cell-death gene ced-3. Genetics 153(4), 1655-71.

Reddien PW, Tanaka EM. (2016). Editorial overview: Cell reprogramming, regeneration and repair Curr Opin Genet Dev 40, iv-vi.